Omega 3 Deficiency Test

The Omega-3 Deficiency Test is a functional assessment used to evaluate the fatty acid composition of the blood, with a focus on omega-3 status and its relationship to cardiovascular health, inflammation, brain function, and overall cellular health.

Omega-3 fatty acids — particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) — are essential components of cell membranes throughout the body. They cannot be produced in sufficient quantities by the body alone and must come from diet or supplementation. Suboptimal omega-3 levels are widespread and have been associated with increased cardiovascular risk, chronic inflammation, cognitive decline, and hormonal imbalance.

Testing measures fatty acid levels directly from red blood cell membranes, which reflect longer-term dietary intake and metabolism more accurately than plasma testing. Results are used to identify deficiencies, assess inflammatory fatty acid ratios, and guide targeted nutritional protocols.

What The Test Evaluates

The Omega-3 Deficiency Test measures 24 individual fatty acids across the following categories:

Omega-3 fatty acids:

• Omega-3 Index (EPA + DHA as a percentage of total red blood cell fatty acids)
• EPA (eicosapentaenoic acid)
• DHA (docosahexaenoic acid)
• ALA (alpha-linolenic acid)
• DPA (docosapentaenoic acid)

Omega-6 fatty acids:

• Linoleic acid
• Arachidonic acid (AA)
• Six additional omega-6 fatty acids

Key ratios:

• Omega-6:Omega-3 Ratio (target range: 3–5:1)
• AA:EPA Ratio (arachidonic acid to EPA, a marker of systemic inflammatory balance)

Trans fat assessment:

• Trans Fat Index (measuring industrially produced trans fats; target below 1%)

Saturated and monounsaturated fatty acids:

• Palmitic acid, stearic acid, oleic acid, palmitoleic acid, and additional individual markers

How The Test Works

The test is carried out using a small finger-prick blood spot sample collected at home using the provided kit. The dried blood spot is then sent to the certified laboratory for analysis using a validated and standardised methodology used in over 200 published research studies.

Results are delivered within 2–4 weeks of the laboratory receiving the sample and include a personalised report with reference ranges and individual fatty acid levels.

Who This Test Is For

This test is used for individuals presenting with or concerned about:

• Low dietary intake of oily fish or omega-3 supplementation
• Cardiovascular risk factors including elevated triglycerides or high blood pressure
• Chronic or systemic inflammation
• Brain fog, poor concentration, or cognitive decline
• Low mood, anxiety, or depression
• Fatigue or poor recovery from exercise
• Hormonal imbalances with an inflammatory component
• Skin conditions including dryness, eczema, or psoriasis
• Proactive assessment of fatty acid status as part of a broader functional medicine or longevity evaluation

The Omega-3 Index is considered a risk factor for cardiovascular disease in its own right. A desirable Omega-3 Index is 8% or above; levels below 4% are associated with significantly increased risk.

What The Service Includes

• Omega-3 Deficiency Test measuring 24 individual fatty acids from a dried blood spot sample
• At-home collection kit with full instructions and pre-paid return envelope
• Laboratory analysis using a validated, standardised methodology
• Comprehensive results report including Omega-3 Index, Omega-6:Omega-3 Ratio, AA:EPA Ratio, Trans Fat Index, and all individual fatty acid levels with reference ranges
• Results reviewed and interpreted by Dr. Menka Gupta within the context of your clinical presentation, health history, and functional medicine goals
• Personalised dietary and supplementation recommendations to optimise fatty acid status

Preparation Guidelines

No fasting is required prior to sample collection. Follow the collection instructions provided with the kit. For most accurate results, collect the sample before taking any omega-3 supplements on the day of testing, and ensure hands are warm to facilitate an adequate blood spot sample.

Disclaimer: These services do not fall under the Singapore Health Services Act. Dr. Menka Gupta holds an MBBS degree and practices functional medicine. Please consult your primary care provider for medical advice, diagnosis, or treatment. Information provided is not a substitute for medical advice.

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